Denver Broncos running back Juwan Thompson (40) runs as San Francisco 49ers inside linebacker Michael Wilhoite defends during the second half of an NFL football game Sunday, Oct. 19, 2014, in Denver. (AP Photo/Joe Mahoney)

Denver beats San Francisco 42-17

Manning went into the showdown two TDs shy of Brett Favre's record of 508, and threw four touchdown passes to reach 510.